29 Jun

My pea brain is busting but a anecdotal comment seems Ok : )
Many Older Dr. I have worked with have been long time fans of anti inflammatory medications and the smart ones are using these effectively to treat a number of different symptoms. I did however think that there was a CV risk from these medications?

Old CardioBrief

Two large new meta-analyses published in the Lancet provide the first strong evidence demonstrating a cause-and-effect relationship between a specific inflammatory protein and the development of coronary heart disease (CHD). Both studies illuminate the role of interleukin-6 receptor (IL6R) by focusing on the common Asp 358Ala variant of the IL6R gene. The variant is known to dampen the inflammatory effect of IL6R.

In the first study, members of the IL6R Genetics Consortium Emerging Risk Factors Collaboration found that Asp358Ala was present in 39% of the population, and was not significantly related to other risk factors. 358Ala increased concentrations of IL6R and interleukin 6 and decreased concentrations of CRP and fibrinogen. Importantly, each copy of 358Ala was associated with a 3.4% reduction in the risk of CHD.

In the second study, members of the Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium performed a Mendelian randomization to analyze the impact on CHD of tocilizumab, an…

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